Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Chinese Marine Materia Medica

China is one of the first countries to use marine materia medica for treating diseases. Ancient books on Chinese herbology, such as Shennong Bencaojing (Shennong's Classic of Materia Medica), Xinxiu Bencao (Newly Revised Materia Medica) and Bencao Gangmu (Compendium of Materia Medica), have detailed more than 110 marine herbs and thousands of marine herbal formulas (including those for Chinese ...

P157: Periostin Recruits Tumor Associated Macrophages in Glioblastoma Multiform

Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis.  In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...

Selective targeting of tumor associated macrophages in different tumor models

Tumor progression largely depends on the presence of alternatively polarized (M2) tumor-associated macrophages (TAMs), whereas the classical M1-polarized macrophages can promote anti-tumorigenic immune responses. Thus, selective inhibition of M2-TAMs is a desirable anti-cancer approach in highly resistant tumor entities such as hepatocellular carcinoma (HCC) or breast cancer. We here examined w...

Materia Medica

Materia Medica